
Gates termasuk salah seorang pengusaha revolusi komputer pribadi terkenal di dunia. Meski demikian, taktik bisnisnya dikritik karena dianggap anti-kompetitif. Pada tahap-tahap akhir kariernya, Gates melakukan beberapa usaha filantropi dengan menyumbangkan sejumlah besar dana ke berbagai organisasi amal dan program penelitian ilmiah melalui Bill & Melinda Gates Foundation yang didirikan tahun 2000.
Gates mengundurkan diri dari jabatannya sebagai pejabat eksekutif tertinggi Microsoft pada bulan Januari 2000. Ia masih menjabat sebagai ketua dan membentuk jabatan kepala arsitek perangkat lunak. Pada Juni 2006, Gates mengumumkan bahwa ia akan bekerja paruh waktu di Microsoft dan purna waktu di Bill & Melinda Gates Foundation. Ia melimpahkan secara bertahap semua pekerjaannya kepada Ray Ozzie, kepala arsitek perangkat lunak, dan Craig Mundie, pejabat riset dan strategi tertinggi Microsoft. Hari kerja purna waktu terakhir Gates di Microsoft adalah 27 Juni 2008. Saat ini, ia masih bekerja di Microsoft sebagai ketua non-eksekutif.

Starting in 1987, Gates was included in the Forbes list of the world's wealthiest people and was the wealthiest from 1995 to 2007, again in 2009, and has been since 2014. Between 2009 and 2014, his wealth doubled from US$40 billion to more than US$82 billion.[9] Between 2013 and 2014, his wealth increased by US$15 billion. Gates is currently the wealthiest person in the world with a net worth of US$77.3 billion.
Gates is one of the best-known entrepreneurs of the personal computer revolution. Gates has been criticized for his business tactics, which have been considered anti-competitive, an opinion that has in some cases been upheld by numerous court rulings.[12][13] Later in his career Gates pursued a number of philanthropic endeavors, donating large amounts of money to various charitable organizations and scientific research programs through the Bill & Melinda Gates Foundation, established in 2000.
Gates stepped down as chief executive officer of Microsoft in January 2000. He remained as chairman and created the position of chief software architect for himself. In June 2006, Gates announced that he would be transitioning from full-time work at Microsoft to part-time work, and full-time work at the Bill & Melinda Gates Foundation.[15] He gradually transferred his duties to Ray Ozzie (chief software architect) and Craig Mundie (chief research and strategy officer).[16] Ozzie later left the company. Gates's last full-time day at Microsoft was June 27, 2008. He stepped down as chairman of Microsoft, in February 2014, taking on a new post as technology adviser to support newly appointed CEO Satya Nadella.